Gene information
Official symbol HPSE
Official full name heparanase
Gene type protein-coding gene
Chromosome4q21.23
Alias symbolHPA; HSE1; HPSE1
Gene familyHeparanases
Resources
Entrez Gene 10855
HGNC HGNC:5164
Ensembl ENSG00000173083
Vega OTTHUMG00000130425
UCSC uc003hok.4
GO terms: 47 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001885 endothelial cell development GO Biological Processes -5.33490415 11 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0003158 endothelium development GO Biological Processes -13.1102461 25 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0006022 aminoglycan metabolic process GO Biological Processes -3.10129957 14 More
GO:0006029 proteoglycan metabolic process GO Biological Processes -1.75242915 4 More
GO:0006516 glycoprotein catabolic process GO Biological Processes -2.33547552 3 More
GO:0007160 cell-matrix adhesion GO Biological Processes -9.58867374 15 More
GO:0009100 glycoprotein metabolic process GO Biological Processes -1.91494967 10 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010575 positive regulation of vascular endothelial growth factor production GO Biological Processes -10.362168 13 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030203 glycosaminoglycan metabolic process GO Biological Processes -2.99315950 13 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035580 specific granule lumen GO Cellular Components -14.6396218 15 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042581 specific granule GO Cellular Components -15.6202777 22 More
GO:0043202 lysosomal lumen GO Cellular Components -6.22272327 10 More
GO:0043394 proteoglycan binding GO Molecular Functions -12.1259478 11 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045446 endothelial cell differentiation GO Biological Processes -10.3072059 20 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061028 establishment of endothelial barrier GO Biological Processes -4.39154198 8 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1901136 carbohydrate derivative catabolic process GO Biological Processes -3.37180259 9 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903510 mucopolysaccharide metabolic process GO Biological Processes -2.64314024 10 More
Drug-Gene interaction
view
Related drugs: 13 records
Drug name Interaction type Source PMID View
amodiaquine hydrochloride DTC 23415087 view
amopyroquine DTC 23415087 view
astemizole DTC 23415087 view
chembl375673 DTC 23415087 view
heparin TdgClinicalTrial view
hesperidin DTC 23415087 view
labetalol DTC 23415087 view
metergoline DTC 23415087 view
muparfostat inhibitor TdgClinicalTrialChemblInteractions view
naringin DTC 23415087 view
rel-cisapride DTC 23415087 view
suramin TTD view
thrombin NCI 1612123 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
heparanase proteomics medium predictor high thrombus burden[prognosis (bad)] acute ST elevation myocardial infarction Gurbuz AS et al. Biomarkers. 2019
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